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Hospital/Department Introduction
Welcome and Introduction – Dr. Di Ge (China)
Case Introduction – Dr. Di Ge (China)
Lobectomy After Neoadjuvant Therapy. Part 1 – Dr. Di Ge (China)
Key Decision 1 Question – Dr. Alessandro Brunelli (UK) and Dr. Di Ge (China)
Lobectomy After Neoadjuvant Therapy. Part 2 – Dr. Di Ge (China)
Key Decision 2 Question – Dr. Douglas E. Wood (USA) and Dr. Di Ge (China)
Lobectomy After Neoadjuvant Therapy. Part 3 – Dr. Di Ge (China)
Key Decision 3 Question – Dr. Alessandro Brunelli (UK) and Dr. Di Ge (China)
Lobectomy After Neoadjuvant Therapy. Part 4 – Dr. Di Ge (China)
Key Decision 4 Question – Dr. Douglas E. Wood (USA) and Dr. Di Ge (China)
Panel Discussion - All faculty moderated by Dr. Di Ge (China)
Clinical case
Clinical history
Male, 65 years old
Found an occupying lesion in the right upper lobe 2 months ago
History: NS
Physical Examination: (-)
Pulmonary function:
-FEV1 : 2.04L,
-FEV1%: 81.34% of predicted value
EKG: (-)
PET/CT Scan
Bronchoscopy + EBUS-TBNA(Lymph node station 4R)
Aug 3rd, 2022
Lymph node station 4R: Squamous cell carcinoma (Low differentiation)
-PD-L1 (28-8) (tumor -, 5% interstitial, TPS=0, CPS=5);
-PD-L1 (E1L3N) (tumor -, 5% interstitial, TPS=0, CPS=5)
Clinical Staging: cT3N2M0, IIIB - Preoperative Treatment (MDT)
Neoadjuvant Chemotherapy +ICIs based on III clinical studies Checkmate816
Treatment date: Aug 12th, Sep 2th, Sep 27th, 2022
Treatment plan: Albumin paclitaxel 440mg d1 + Carboplatin 435mg d1 + Nivolumab 200mg d1 q3w
Adverse reaction: Transient leukopenia occurred during the 2nd course of treatment, but was cured promptly was no delay in the subsequent treatment
Radiological outcome: Partial Response (PR)
Date of Operation: Oct 18th, 2022
Pathologic outcomes
Major Pathological Response (MPR), Downstage
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