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Peritoneal carcinomatosis (PC) is a common disease with poor prognosis. From colorectal carcinoma (CRC) origin, 19% of the patients will metachronically present with PC. These patients usually suffer from cachexia, ascites, and other symptoms that made them very challenging patients. Palliative chemotherapy showed a limited improvement in overall survival despite new target therapies. Cytoreductive surgery (CRS) + Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is the gold standard treatment for selected patients with PC of colorectal origin.