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Effective healthcare innovation requires active and early engagement of key stakeholders—patients, industry, healthcare authorities, and academia—to ensure that new solutions are practical, sustainable, and widely adopted. This presentation examines historical case studies, such as Pfizer's Exubera and Google Health, where limited stakeholder involvement led to significant market and operational challenges. The discussion underscores the importance of a multidisciplinary approach in designing patient-centered innovations, highlighting methods such as focus groups, patient advisory boards, and industry-academic partnerships. Furthermore, the role of healthcare authorities in regulatory support and academia's contribution to foundational research are emphasized. Key strategies for overcoming collaboration barriers include open communication, shared objectives, and governance structures that foster impactful, scalable healthcare advancements. This roadmap provides a framework for improving outcomes in surgical and healthcare interventions through comprehensive stakeholder engagement.