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It is clear that stage-III and stage-IV colorectal cancer has a decreased long-term survival (from 83% to 8.1% depending on the specific stage). Metastasis can affect the lymph nodes or distant organs like the liver, lung, brain and bones.
During the last 3 decades, research has focused on understanding the molecular phenomena involved in the evolution of the primary tumor. But what about the mechanism involved in the evolution of the metastatic disease?
In this lecture, Jelena Urosevic will explain the current data obtained from experimental models focusing on understanding metastatic progression as well as genes, the signaling pathways identified and their potential clinical implications.