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The SWOG Clinical Trials Lung Committee event featured an update on SWOG's current trials and the evolving landscape of surgical involvement in clinical trials. The speaker emphasized the competition between collaborative groups and the pharmaceutical industry in conducting trials.
A trial for surgical resectable patients is nearing completion, but challenges exist with standard of care and trial readouts. The speaker highlighted the importance of profiling patients upfront for effective neoadjuvant therapies and discussed ongoing trials. This phase II trial compares chemo-radiation with Atezolizumab to standard care, focusing on pathological complete response as the primary objective. Another active trial involves pediatric surgeons comparing open and VATS approaches for pulmonary metastasis in osteosarcoma patients under 50 years old.
The eligibility criteria stress control of the primary disease and specific characteristics of pulmonary lesions. The aim is to determine if open surgical resection is superior in terms of event-free survival. The speaker concluded by highlighting the importance of surgeons collaborating with pulmonologists and adapting to the changing paradigm in patient profiling for optimal treatment strategies.
